The Forschungszentrum Jülich (FZJ) is one of the 18 Helmholtz Research Centres in Germany. The Institute of Neuroscience and Medicine (INM) of FZJ focuses on the structure and function of the healthy and diseased human brain. It has longterm experience and expertise in understanding the structural and functional changes caused by neurological and psychiatric disorders for the improvement of early diagnosis and treatment. Scientists from various disciplines work at the INM, employing state-of-the-art imaging techniques such as structural and fMRI, PET, microanatomy, cell biology, genetics, and the methods used in physics and information science. The INM is also a core partner of the JARA-Brain (Jülich-Aachen-Research-Alliance), a structural partnership that integrates the resources of the RWTH at Aachen and the FZJ. It provides a unique platform for interdisciplinary research on mental health that combines the knowledge and skills of physicists, engineers, mathematicians and physicians.
In WP2, the FZJ will provide the facilities to carry out the studies described. The FZJ has a working 3T BrainPET that is equipped with simultaneous EEG; patient studies will be carried out using this machine to search for suitable biomarkers. In addition, the 9.4T PET/MR instrument will be used for the same task whereby the results at this high field will be translated to 3T. In WP4, expertise will be provided for the design of gradient coils and shim coils. The design of an 8-channel RF coil will also be provided in collaboration with UNIPI. Regarding WP5, the FZJ will contribute to PET image reconstruction by virtue of the fact that PRESTO was developed by us. The FZJ will lead WP6, the integration of the trimodal scanner. Here, prior experience with the development and construction of prototype PET/MR scanners is deemed to be essential. The work performed in WP6 will facilitate the clinical studies to be carried out under the leadership of JBR; these studies will be performed in the FZJ.